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Chlorpropamide is a white crystalline powder, that has a slight odor. It is practically insoluble in water at pH 7.3 (solubility at pH 6 is 2.2 mg/mL). It is soluble in alcohol and moderately soluble in chloroform. The molecular weight of chlorpropamide is 276.74. Diabinese is available as 100 mg and 250 mg tablets.

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2. Abbreviation for dibenzo[b,e][1,4]dioxin which may be visualized as an anhydride of two molecules of 1,2-benzenediol (pyrocatechol), thus forming two oxygen bridges between two benzene moieties, or as a 1,4-dioxin with a benzene ring fused to catch each of the two CH=CH groups.

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There is no fixed dosage regimen for the management of type 2 diabetes with DIABINESE or any other hypoglycemic agent. The patient s blood glucose must be monitored periodically to determine the minimum effective dose for the patient; to detect primary failure, i.e., inadequate lowering of blood glucose at the maximum recommended dose of medication; and to detect secondary failure.
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DIABINESE (chlorpropamide) appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which DIABINESE (chlorpropamide) lowers blood glucose during long-term administration has not been clearly established.
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Renal glycosuria is a rare condition in which the simple sugar is excreted in the urine despite normal or low blood glucose levels. With normal kidney (renal) function, glucose is excreted in the urine only when there are abnormally elevated levels of glucose in the blood.
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Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome (PCOS).
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**FDA Disclaimer: These statements have not been evaluated by the FDA and are not intended to diagnose, cure or prevent any disease. Please consult your physician before beginning any diet or exercise program.




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